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KMID : 0525619980030010101
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1998 Volume.3 No. 1 p.101 ~ p.110
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Synthesis and bioactivity of N - Conjugated Chitosan Oligosaccharide Derivatives With Amino Acids
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전유진/Jeon YJ
김세권/Kim SK
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Abstract
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Antimicrobial activity of chitosan oligosaccharide (COS) derivatives N-conjugated with various amino acids(AA) have been investigated against E. coli. The syntheses of chitosan oligosaccharide derivatives (AA-COS) by DCC addition were carried out for reaction time 4hrs in a mixture solution with Immol of COS and 5mmol of AA and the degree of subsitution of AA-COS was 72.4% by ninhydrin method. All derivatives are greatly water-soluble. Asn-COS among all derivatives completely inhibited bacterial growth and had outstanding bactericidal activity. Antimicrobial action of Asn-COS might be dependent on the neighboring another free amino group at free amino group on back bone in the chemical structure of Asn-COS. These results suggest that Asn-COS would be useful as a new antibiotic agent.
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KEYWORD
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